Cholesterol metabolism in pantothenic acid deficiency.
نویسندگان
چکیده
منابع مشابه
The modification of choline deficiency by simultaneous pantothenic acid deficiency.
It was found recently (1) that feeding a cholesterol-rich diet to pantothenic acid-deficient rats did not result in the fatty livers and high levels of cholesterol in liver and serum seen in comparable animals maintained on a normal diet. Decrease in food intake appeared not to account for this phenomenon, since the food intake of the deficient group on a body weight basis was higher than that ...
متن کاملAn assay for pantothenic acid in biologic fluids.
ANTOTHENIC ACID DEFICIENCY reduces biologic actylations and leads to a variety of pathologic changes in blood cholesterol partition and antibody production. Deficiency affects particularly the adrenal cortex, nervous system, the skin, and hair; it also affects longevity (1, 2, 3, 4). The ubiquity of pantothenic acid (as suggested by its name), makes it difficult to demonstrate deficiencies, eve...
متن کاملThe metabolism in vitro of cardiac muscle in pantothenic acid deficiency.
An important r81e for pantothenic acid in carbohydrate metabolism was suggested by studies in which pantothenic acid-deficient bacteria (1, 2) and liver (3) were observed to utilize pyruvate at rates much less than normal. The subsequent discovery of Lipmann and his colleagues that the coenzyme of acetylation (coenzyme A) (4) contained pantothenic acid (5) provided a stimulus for the reinvestig...
متن کاملPantothenic acid deficiency induced in human subjects.
Bean and Hodges (1) gave a preliminary report of four young men in whom clinical disorders and metabolic faults were induced by a "diet" devoid of pantothenic acid, with omega-methylpantothenic acid, a vitamin antagonist (Figure 1). It is proposed here to describe details of the experiments, results, and some interpretations. The background for using molecular antagonists (2, 3) in human nutrit...
متن کاملCarbohydrate metabolism and adrenal cortical function in the pantothenic acid-deficient rat.
A relationship between pantothenic acid and the adrenal gland has been evident since the earliest work with this vitamin was done. Morgan and Simms (1) found pathologic changes in the adrenals of rats on diets free from “filtrate factor,” and reported (2) that the achromotrichia of rats maintained on these diets could be at least partly reversed by extracts of the thyroid and of the adrenal cor...
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 197 2 شماره
صفحات -
تاریخ انتشار 1952